Direct cloning method CAPTUREs novel microbial natural products

Direct cloning method CAPTUREs novel microbial natural products

Direct cloning method CAPTUREs novel microbial natural products

Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at University of Illinois Urbana-Champaign previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery.
Direct cloning method CAPTUREs novel microbial natural products