Neural activity controls mitochondrial transfer of RNA modifiers to the nucleus

Neural activity controls mitochondrial transfer of RNA modifiers to the nucleus

Neural activity controls mitochondrial transfer of RNA modifiers to the nucleus

In a recent paper in RNA Biology, researchers show that mitochondria translocate their key RNA methyltransferase enzyme, TRMT1, into host cell nuclei in response to neural activity. This subcellular relocalization of key RNA modifiers suggests a new understanding of how neurons plastically reconfigure their nuclei as network dynamics change.
Neural activity controls mitochondrial transfer of RNA modifiers to the nucleus